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Current clinical guidelines from major organizations including the American Diabetes Association (ADA) and the American Gastroenterological Association (AGA) do not specifically address combining tirzepatide with orlistat, reflecting the absence of robust clinical trial data for this combination

Starting with a low dose and increasing gradually helps minimize discomfort

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In addition, the number of participants who were and were not affected by type 2 diabetes was similar (43 vs 52), enabling these results to potentially apply to both patient populations

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